2 edition of Evaluation of transmyocardial acupuncture in experimental myocardial ischemia in the dog. found in the catalog.
Evaluation of transmyocardial acupuncture in experimental myocardial ischemia in the dog.
Patrick Joseph McKeever
Written in English
|The Physical Object|
|Pagination||ix, 64 l.|
|Number of Pages||64|
Refractory angina pectoris in coronary artery disease is defined as the persistence of severe anginal symptoms despite maximal conventional antianginal combination therapy. Further, the option to use an invasive revascularization procedure such as percutaneous coronary balloon angioplasty or aortocoronary bypass grafting must be excluded on the basis of a recent . PURPOSE: To monitor perfusion changes in remote myocardium caused by transmyocardial laser revascularization (TMLR) and to investigate the influence of TMLR on left ventricular morphology and funct Cited by: Myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus Akram Shmendi,1 Fraser Pirie,2 Datshana P Naidoo,3 Boikhutso Tlou,4 Wilfred Pilloy,5 Ayesha A Motala2 1Department of Medicine, 2Department of Diabetes and Endocrinology, 3Department of Cardiology, . In , Karl Huber reported on 17 patients with cardiac infarcts, which he attributed to occluded coronary arteries.: The prime focus in the treatment of an AMI in the s and s was on the re-establishment of flow in the acutely occluded coronary artery.: Patients then underwent a coronary angiogram and electromechanical mapping of the heart in a cardiac catheterization .
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Heart of a dog sacrificed 6 weeks after transmyocardial acupuncture and occlusion of the left circumflex artery. Large myocardial infarction in the diaphragmatic wall.
Fig. Microscopic section of the posterior wall of the left ventricle shows the scar of a myo cardial by: These channels, created by transmyocardial acupuncture, effectively meet the challenge of acute coronary artery occlusion, as is shown by experimental studies.
Multiple Transmyocardial Puncture Revascularization in Refractory Ventricular Fibrillation due to Myocardial Ischemia Manuel White, M.D., and John E. Hershey, M.D. n Sen, Udwadia, Kinare, and Parulkar [ S ] of Bombay, India, reported the creation of multiple transmyocardial puncture tracts as an effective new approach to myocardial by: In each and every animal studied, evaluation was carried out using cine-angiography, lissamine green dye injections, and study to observe the onset of ventricular fibrillation with myocardial by: In the present study we evaluated infarcted and stunned myocardium in an experimental model using real time myocardial contrast echocardiography.
Sixteen dogs underwent min of coronary occlusion followed by reperfusion (infarct model) and seven other dogs were submitted to 20 min of coronary occlusion followed by reperfusion (stunned model). In these experiments, transmyocardial laser revascularization was performed in canine models of acute myocardial ischemia using a variety of lasers (13, 22).
To evaluate the short- and long-term efficacy of transmyocardial laser revascularization, we used a carbon dioxide laser in an ovine model of acute myocardial by: Further evaluation of myocardial function such as radioisotope scan or stress function tests is often required after identifying coronary artery stenosis lesions that also requires costs and additional radiation exposure.
With the advance of CT and MRI, myocardial perfusion is easily and reliably : Joon-Won Kang, Sung Min Ko. Transmyocardial laser revascularization (TMLR), one such therapy currently under active clinical investigation, has received a great deal of attention because results of several studies indicate that it provides significant relief of angina and may improve myocardial perfusion in otherwise untreatable patients 1, 2, 3, by: Unmodified reperfusion therapy for acute myocardial infarction (AMI) is associated with irreversible myocardial injury beyond that sustained during ischemia.
Studies in experimental models of ischemia/reperfusion and in humans undergoing reperfusion therapy for AMI have examined potential beneficial effects of nitric oxide (NO) supplemented at Cited by: Abstract.
Transmyocardial laser revascularization (TMLR) is currently under investigation as a novel means for augmenting regional myocardial blood flow in coronary artery disease patients unsuitable for percutaneous transluminal angioplasty Author: Heiko Schöder, Heinrich R.
Schelbert. Randomized controlled trials that compared the effects of surgical TMR with those of maximal medical management were published. In these reports, TMR was. Evaluating Ischemia-Reperfusion Injury in the Pig.
Porcine animal models of myocardial ischemia that allow for the investigation of reperfusion injury have been established for almost three decades .This preference may be explained by two main factors: first, pigs and their hearts come in a size that allows for use of patient-devised : Andrea Baehr, Nikolai Klymiuk, Christian Kupatt.
In the setting of ischemia, experimental studies have shown that strain imaging was an accurate method for quantitative evaluation of regional myocardial Evaluation of transmyocardial acupuncture in experimental myocardial ischemia in the dog.
book and may yield important physiological data. In myocardial infarction, transmural extension of scar distribution in the. Recovery and viability of an acute myocardial infarct after transmyocardial laser revascularization February Journal of the American College of Cardiology 25(1) Transmyocardial laser revascularization channels made with this CO2 laser did not provide acute myocardial perfusion or preserve myocardial viability in the face of acute ischemia.
Transmyocardial laser revascularization is a new therapy for patients with refractory angina. Although clinical studies suggest that transmyocardial laser revascularization decreases angina and may improve regional blood flow, the underlying mechanisms are not elucidated.
Transmyocardial revascularization (TMR) is a puncture technique proposed as a solution for patients with coronary artery disease who cannot be efficiently treated with the standard revascularization procedures such as bypass surgery or percutaneous transluminal coronary angioplasty (PTCA).
The studies presented in this review have investigated the use of lasers. Another is to discuss the effects of ischemia on myocardial contraction immediately after the onset of ischemia, during the steady-state and with chronic ischemia and infarction. Finally, we will examine the reversibility of derangements in myocardial function with reperfusion after brief coronary artery occlusions insufficient to induce Author: David A.
Cox, Stephen F. Vatner. InMirhoseini et al demonstrated that the carbon dioxide laser could generate small transmyocardial channels in the ischemic myocardium of a dog. InMirhoseini et al used TMLR on a patient with CAD, [ 5 ] employing a carbon dioxide laser in conjunction with CABG to treat a hypokinetic area of the left ventricle.
Objectives. This study sought to test whether transmyocardial laser revascularization (TMLR) stimulates angiogenesis in an animal model of chronic ischemia. Background. TMLR relieves angina and may also improve blood flow in patients who are not candidates for traditional therapies.
The mechanisms of these benefits are not fully defined. Cited by: Transmyocardial laser revascularization (TMLR) is a surgical procedure which is used as an ultimaratio method in the treatment of severe diffuse coronary disease.
Transmyocardial channels are created in the free wall of the left ventricle by use of a by: 1. In the past 35 years many experimental studies have been performed to investigate the revascularization potential of transmyocardial revascularization and the possible working mechanisms underlying the observed clinical improvement in angina pectoris after this treatment.
In this review of the experimental literature, the various methods that have been used to create transmyocardial Cited by: The accepted gold standard blood marker for myocardial ischemia is myocardial lactate extraction. Simultaneous IMA and lactate was measured in 10 patients undergoing PCI for chronic stable angina.
Post-PCI IMA concentrations paralleled that of transmyocardial lactate. Elevation in serum IMA has been recorded following coronary vasospasm Cited by: 3.
JACC Cardiovasc Imaging. Mar;7(3) doi: / Epub Feb Dynamic myocardial CT perfusion imaging for evaluation of myocardial ischemia as determined by MR by: After varying periods of cessation of electrical activity of the heart (up to a maximum of 20 minutes), the cadavers were perfused by means of a pump-oxygenator, to maintain the viability of the donor hearts.
Sen and his team used upper-body perfusion (40 cases) (Fig. 4A), total-body perfusion (20 cases) ( by: 5. In addition to the difficulty of injecting blindly into the left ventricle, intracardiac injections can result in numerous complications, including coronary vessel laceration, myocardial ischemia, hemorrhage, arrhythmia, and pneumothorax.
16,Medication administered via a peripheral catheter should be given as a bolus injection Cited by: 1. j thorac cardiovasc surg. aug; transmyocardial acupuncture: a new approach to myocardial revascularization.
sen pk, udwadia te, kinare sg, parulkar by: Late gadolinium enhanced (LGE) CMR is the gold standard for visualizing myocardial infarction (MI), but the impact of different CAs on LGE visualization and quantification is unknown.
Methods MI was induced in 4 dogs by left anterior descending (LAD) coronary artery ligation for 90 minutes with by: 2. Transmyocardial laser revascularization has been used as an indirect approach to improve myocardial perfusion in patients with refractory angina not amenable to conventional therapy.
Three mechanisms have been proposed for its therapeutic effects: direct perfusion of the ischemic myocardium through patent channels; induction of angiogenesis; and regional Cited by: FIG.
Normal wall motion M-mode (motion mode). Normal inward endocardial excursion and wall thickening are illustrated on an M-mode image through the inferior (top) and anterior (bottom) walls in the transgastric short-axis view (top inset).Systole starts at the onset of the QRS complex and ends near the end of the T wave (arrows).M-mode imaging through transesophageal.
Myocardial contrast echocardiography is an evolving method that has the potential to assess myocardial perfusion in patients with acute coronary artery disease (2). The method has been validated for the assessment of risk area and infarct size during total coronary occlusion in experimental models ().
However, previous techniques using inter. Stress echocardiography is an established technique for the assessment of extent and severity of coronary artery disease.
The combination of echocardiography with a physical, pharmacological or electrical stress allows to detect myocardial ischemia with an excellent accuracy.
A transient worsening of regional function during stress is the hallmark of inducible by: In a porcine model of brief ischemia leading to reversible stunning in the absence of tissue necrosis, we demonstrated delayed release of cardiac troponin I (cTnI) that exceeded the 99th percentile for normal animals 60 min after reperfusion and rose to readily detectable levels 24 h later.
Although tissue analysis at 60 min showed no evidence of infarction, TUNEL Cited by: Long- and short-term effects of transmyocardial laser revascularization in acute myocardial ischemia Kamuran A. Kadipasaoglu, Seckin Pehlivanoglu, Jeff L. Conger, Eisaku Sasaki, Diego Hernan de Villalobos, Michael Cloy, Vitaly Piluiko, Fred Cited by: Further studies in multiple transmyocardial acupuncture as a method of myocardial revascularization.
Surgery. ; Medline Google Scholar; 16 White M, Hershey JE. Multiple transmyocardial puncture revascularization in refractory ventricular fibrillation due to myocardial ischemia. Ann Thorac Surg. ; Crossref Medline Cited by: cardiogram in myocardial ischemia, first noted by Pardee (1) inhas been accepted for many years as the major diagnostic criterion ofacute myo-cardial infarction (2) or its extension (3).
Its electro-physiological correlates were established by Samson and Scher (4) who showed that acute epicardial ST-segment shifts in ischemia were due to.
In Step 3, the Back-Shu or Abdomen-Mu points sensitive to palpation were find the sensitive Shu (Figure 4(a)) or Mu (Figure 4(b)) points on back and abdomen, the right hand palpated the skin on Back-Shu and Abdomen-Mu points while the left hand was positioned on abdomen.
The points at which dogs exhibited the protective abdominal reflex, skin twisting, Cited by: 3. Limited Myocardial Muscle Necrosis Model Allowing for Evaluation of Angiogenic Treatment Modalities. Journal of Reconstructive Microsurgery, 22, The currently accepted model for creating infarcted cardiac tissue in a rat model involves ligation of the left anterior descending artery (LAD), either proximally or at the bifurcation on: South Peoria Avenue Tulsa, OK, United States.
However, a SPECT without evidence of ischemia, does not explain ischemic electrocardiographic changes triggered by physical stress, although it is a good marker prognostic.
A CTP is a emerging tool in the evaluation of myocardial ischemia. Recent studies point to a good accuracy of the method compared to nuclear medicine. Attempted cardiac revascularization through laser-made channels has gained considerable recent notoriety.
Although the treatment reduces angina, its ability to enhance perfusion is unclear, and the mechanism of action unknown. The fate of the channels appears an obvious place to look for insight. Therefore, this review focuses on temporal and spatial changes in channel by:. Myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus Akram Shmendi,1 Fraser Pirie,2 Datshana P Naidoo,3 Boikhutso Tlou,4 Wilfred Pilloy,5 Ayesha A Motala2 1Department of Medicine, 2Department of Diabetes and Endocrinology, 3Department .in a year-old man with myocardial ischemia and resultant refractory ventricular fibrillation.
Revascu- larization was accomplished with prolonged inter- mittent cardiac compression and transmyocardial acupuncture with a mm knobbed cannula. The cannula was used to create 85 channels on the left.Myocardial 18F-FDG Uptake After Exercise-Induced Myocardial Ischemia in Patients with Coronary Artery Disease Ke-Fei Dou*1, Min-Fu Yang*2, and molecular biology of myocardial ischemia.
In experimental animal studies, upregulation of glucose for the evaluation of 18F-FDG as a memory marker of myocardial ischemia.